Alexis Melton, MD, PhD

HS Assoc Clinical Professor
Pediatrics
+1 415 476-2188

Dr. Melton is an attending physician on both the Bone Marrow Transplant and the general pediatric Hematology/Oncology unit, thus she will be knowledgeable and help with the implementation of the study across both sites. Further, she is familiar with the clinical setting and treatment schedules for children with brain tumors who are receiving daily radiation treatment and who will be given the option to enroll in the study

Publications: 

Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols.

Transplantation and cellular therapy

Salinas Cisneros G, Dvorak CC, Long-Boyle J, Kharbanda S, Shimano KA, Melton A, Chu J, Winestone LE, Dara J, Huang JN, Hermiston ML, Zinter M, Higham CS

A diagnostic classifier for pediatric chronic graft-versus-host disease: results of the ABLE/PBMTC 1202 study.

Blood advances

Cuvelier GDE, Ng B, Abdossamadi S, Nemecek ER, Melton A, Kitko CL, Lewis VA, Schechter T, Jacobsohn DA, Harris AC, Pulsipher MA, Bittencourt H, Choi SW, Caywood EH, Kasow KA, Bhatia M, Oshrine BR, Chaudhury S, Coulter D, Chewning JH, Joyce M, Savasan S, Pawlowska AB, Megason GC, Mitchell D, Cheerva AC, Lawitschka A, Ostroumov E, Schultz KR

A pilot trial of prophylactic defibrotide to prevent serious thrombotic microangiopathy in high-risk pediatric patients.

Pediatric blood & cancer

Higham CS, Shimano KA, Melton A, Kharbanda S, Chu J, Dara J, Winestone LE, Hermiston ML, Huang JN, Dvorak CC

Hematopoietic Cell Transplant-Comorbidity Index Score is Correlated with Treatment Related Mortality and Overall Survival following Second Allogeneic Hematopoietic Cell Transplant in Children.

Transplantation and cellular therapy

Forlanini F, Zinter MS, Dvorak CC, Bailey-Olson M, Winestone LE, Shimano KA, Higham CS, Melton A, Chu J, Kharbanda S

Transplant-associated thrombotic microangiopathy in pediatric patients: pre-HSCT risk stratification and prophylaxis.

Blood advances

Higham CS, Collins G, Shimano KA, Melton A, Kharbanda S, Winestone LE, Huang JN, Dara J, Long-Boyle JR, Dvorak CC

Reduced Toxicity Conditioning for Non-Malignant Hematopoietic Cell Transplants.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Contreras CF, Long-Boyle JR, Shimano KA, Melton A, Kharbanda S, Dara J, Higham C, Huang JN, Cowan MJ, Dvorak CC

The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation.

Pediatric blood & cancer

Friend BD, Bailey-Olson M, Melton A, Shimano KA, Kharbanda S, Higham C, Winestone LE, Huang J, Stieglitz E, Dvorak CC

Reduced Toxicity Conditioning for Non-Malignant Hematopoietic Cell Transplants.

Blood

Cristina F Contreras, Janel R Long-Boyle, Kristin A. Shimano, Jasmeen Dara, James N Huang, Sandhya Kharbanda, Alexis Melton, Christine Higham, Morton J Cowan, Christopher C. Dvorak

Role of Disease Mechanism in Hematopoietic Cell Transplantation Outcomes for Hemophagocytic Lymphohistiocytosis.

Blood

Aleksandra S. Dain, Michelle L. Hermiston, Kristin A. Shimano, Sandhya Kharbanda, Alexis Melton, Jasmeen Dara, James N Huang, Christopher C. Dvorak

Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial.

Global advances in health and medicine

Lown EA, Banerjee A, Vittinghoff E, Dvorak CC, Hartogensis W, Melton A, Mangurian C, Hu H, Shear D, Adcock R, Morgan M, Golden C, Hecht FM

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Zinter MS, Dvorak CC, Mayday MY, Iwanaga K, Ly NP, McGarry ME, Church GD, Faricy LE, Rowan CM, Hume JR, Steiner ME, Crawford ED, Langelier C, Kalantar K, Chow ED, Miller S, Shimano K, Melton A, Yanik GA, Sapru A, DeRisi JL

Autoimmune Cytopenias in Pediatric Hematopoietic Cell Transplant Patients.

Frontiers in pediatrics

Neely JA, Dvorak CC, Pantell MS, Melton A, Huang JN, Shimano KA

Low Exposure Busulfan Conditioning to Achieve Sufficient Multi-lineage Chimerism in Patients with Severe Combined Immunodeficiency.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Dvorak CC, Long-Boyle J, Dara J, Melton A, Shimano KA, Huang JN, Puck JM, Dorsey MJ, Facchino J, Chang CK, Cowan MJ

The Impact of Total Body Irradiation-Based Regimens on Outcomes in Children and Young Adults with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

Biology of Blood and Marrow Transplantation

Brian D. Friend, Mara Bailey-Olson, Christine Higham, Jasmeen Dara, Alexis Melton, Kristin A. Shimano, James Huang, Sandhya Kharbanda, Christopher C. Dvorak

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children.

bioRxiv

Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Kensho Iwanaga, Ngoc P Ly, Meghan E McGarry, Gwynne D Church, Lauren E Faricy, Courtney M Rowan, Janet R Hume, Marie E Steiner, Emily D Crawford, Charles Langelier, Katrina Kalantar, Eric D Chow, Steve Miller, Kristin Shimano, Alexis Melton, Greg A Yanik, Anil Sapru, Joseph L DeRisi

Neurologic event-free survival demonstrates a benefit for SCID patients diagnosed by newborn screening.

Blood advances

Dvorak CC, Puck JM, Wahlstrom JT, Dorsey M, Melton A, Cowan MJ

58 Neurologic-Event-Free Survival (NEFS): A New Endpoint for Severe Combined Immunodeficiency (SCID) Patients Diagnosed by Newborn Screening (NBS) and Treated with Hematopoietic Cell Transplantation (HCT).

Biology of Blood and Marrow Transplantation

Christopher C. Dvorak, Justin T. Wahlstrom, Jennifer Puck, Morna Dorsey, Alexis Melton, Biljana Horn, Morton J. Cowan

Early mixed chimerism-based preemptive immunotherapy in children undergoing allogeneic hematopoietic stem cell transplantation for acute leukemia.

Pediatric blood & cancer

Horn B, Wahlstrom JT, Melton A, Liou A, Ouachee-Chardin M, Sunkersett G, Willert J, Hwang J, Expose-Spencer J, Cowan MC, Facchino J, Dvorak CC

Azacitidine Administration Following Hematopoietic Stem Cell Transplantation Is Safe and Feasible in Children with Acute Leukemia.

Blood

Justin T. Wahlstrom, Biljana N. Horn, Carol Fraser-Browne, Rebecca Hoeweler, Ying Lu, Alexis Melton, Jennifer Willert, Christopher C. Dvorak

Daratumumab Is Effective in the Treatment of Refractory Post-Transplant Autoimmune Hemolytic Anemia: A Pediatric Case Report.

Blood

Vanessa P. Tolbert, Robert Goldsby, James Huang, Kristin Shimano, Alexis Melton, Jennifer Willert, Biljana N. Horn, Christopher C. Dvorak, Justin T. Wahlstrom

Serotherapy-Related Fevers, Blood Stream Infections (BSI), and Antibiotic Use in Pediatric Allogeneic Hematopoietic Cell Transplant (HCT) Recipients.

Biology of Blood and Marrow Transplantation

Biljana Horn, Sara O'Kane, Rachel Wattier, Justin T. Wahlstrom, Alexis Melton, Morton J. Cowan, Christopher C. Dvorak

RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.

Oncogene

Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP

Combinatorial control of signal-induced exon repression by hnRNP L and PSF.

Molecular and cellular biology

Melton AA, Jackson J, Wang J, Lynch KW

 

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